Topiskin Plus Glutathione and Vitamin C patches are safe and effective means for daily health and wellness support!
 
Did you know your body cannot effectively absorb glutathione in a pill?
Theses patches are a simple, safe and effective way to get your daily dose of antioxidants and vitamins. These patches hold a clean and organic transdermal gel infused with 200 mg of S-acetyl-glutathione and 100 mg of vitamin C. When we take oral glutathione supplements our stomach acid denatures the molecules useless. Most oral supplements are GSH or reduced which is not the same as S-acetyl.
No significant changes were observed in biomarkers of oxidative stress, including glutathione status, in a clinical trial of oral glutathione supplementation in healthy adults (see references below). Therefore, you see IV glutathione therapy has become popular but the effects of this only last for 3-5 hours then you feel the same again additionally this requires frequent treatments which can be expensive and not covered by health insurance. Topiskin plus patches are a peel, stick and go system that will last for 24hrs of effective transdermal delivery.
 
 
What is glutathione?
 
Glutathione is a tripeptide (cysteine, glycine, and glutamic acid) found in surprisingly high levels concentrations in most human cells. As we age usually beyond our 20s this declines. Considering the high level of metabolic activity required to produce glutathione, such a high level of support and replenishing the building blocks that the human body uses to make glutathione is critical to aging, growth, quality health, immunity, and detoxification. Glutathione is a very powerful antioxidant that is produced in our liver and serves to help bind to toxins to be expelled through bile as waste. Glutathione also helps maintain integrity of red blood cells and protects the white blood cells. It can mitigate some of the damage caused by tobacco smoke because it modifies the chemical that damage the cell lining which initally cause inflammation and oxidation. Glutathione may also help the liver protecting it from alcohol damage.
 
Glutathione Deficiency Symptoms
 
lack of coordination/balance difficulty
mental disarray/ monkey brain/ Alzheimer's/ Parkinson's
poor sleep/ circadian cycle imbalance
chronic fatigue
frequent infections/ poor immune function
inflammatory skin conditions
thyroid/pancreatic functions (diabetes)
cardiovascular disease/ atherosclerosis
 
Smoking increases the rate of utilization for glutathione both in detoxification of nicotine and neutralization of free radicals, the same is true for alcohol.
 
How to support the use of this Glutathione Patch
 
As mentioned before oral glutathione supplements are not very effective. However, the transdermal patch allows direct absorption through the skin penetrating to entry directly to your blood stream. This process bypasses the hydrochloric acid of the stomach which will render the non-reduced form useless, your body will not be able to absorb the molecules but may recycle them for new glutathione if all of your necessary amino acids are present. The patch is formulated with 100mg of Vitamin C in the form of non gmo ascorbic acid). This helps the glutathione in application of absorbtion via skin. You can support your levels effectivly by having about 500mg of glutathione daily to inrease blood levels for added antioxidant and immune support. See the suggested applications for wear below. When used at this level some have reported clearer skin, and eyes as well as confirmed increased GHS reduced glutathione in their blood test.
 
 
 
 
 
Applications For Wear
 
ensure the location you pick is free of hair, tattoos, and body cosmetics,
clean your skin with rubbing alcohol prior to application
best locations can be seen in the body chart picture, I prefer the shoulder blade and lower neck
 
You can wear for up to 24hrs an average of 6-12hrs 14-15 days at a time/cycle
take a 5 day break before wearing the patches again
 
You can wear up to three patches for a max of 600mg glutathione and 300mg of vitamin C to support bioavailability consume raw leafy greens, and supplement with DHEA and L-cystenine (NAC is synthetic for acetyl cysteine) A B complex of 100mg minimum may also support the metabolism of glutathione.
 
-When wearing patchry to prevent direct water and chemicals from coming in contact with the patch
-patch can be applied after bathing in the am or just before going to bed.
-1 patch contains 200 mg of acetyl-glutathione and 100mg of vitamin C for optimal use in absorption.
-Clinical trials administered 500mg of glutathione supplements before a detected range of GHS blood serums levels changed and skin lightening occurred
 
 
 
 
 
References
 
 
Allen, J., & Bradley, R. D. (2011). Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. Journal of alternative and complementary medicine (New York, N.Y.), 17(9), 827–833. https://doi.org/10.1089/acm.2010.0716
 
Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017;10:147-153. Published 2017 Apr 27. doi:10.2147/CCID.S128339
 
Al Hanbali, O. A., Khan, H. M. S., Sarfraz, M., Arafat, M., Ijaz, S., & Hameed, A. (2019). Transdermal patches: Design and current approaches to painless drug delivery. Acta Pharmaceutica (Zagreb, Croatia), 69(2), 197-215. https://doi.org/10.2478/acph-2019-0016
 
Corcoran, G. B., & Wong, B. K. (1986). Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice. The Journal of pharmacology and experimental therapeutics, 238(1), 54–61.
 
Dilokthornsakul, W., Dhippayom, T., & Dilokthornsakul, P. (2019). The clinical effect of glutathione on skin color and other related skin conditions: A systematic review. Journal of cosmetic dermatology, 18(3), 728–737. https://doi.org/10.1111/jocd.12910
 
Locigno R, 2002, S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. – http://www.ncbi.nlm.nih.gov/pubmed/11743644
 
Okun JG, 2004, S-Acetylglutathione normalizes intracellular glutathione content in cultured fibroblasts from patients with glutathione synthetase deficiency. – http://www.ncbi.nlm.nih.gov/pubmed/15617191
 
Vogel JU, 2005, Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection. – http://www.ncbi.nlm.nih.gov/pubmed/14624358